目前日期文章:201104 (2)

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【Rumack-Matthew nomogram】The original nomogram line separating possible toxicity from unlikely toxicity was based on a 4-hour ACT level of 200 micrograms/mL (1300 micromoles/L), but was subsequently modified in the U.S. by the FDA by moving the line to a 4-hour ACT level of 150 micrograms/mL (1000 micromoles/L) to increase the safety ⋯⋯margin for treatment decisions. The nomogram only directly applies to an ACT level obtained after a single exposure and during the window between 4 and 24 hours postingestion. Outcome prediction using this nomogram cannot be applied to ACT levels obtained outside this 20-hour window or with chronic or recurrent exposures.

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【普 拿疼】成人acetaminophen中毒劑量:(1) >10 g or 200 mg/kg as a single ingestion, (2) >10 g or 200 mg/kg over a 24-hour period, or (3) >6 g or 150 mg/kg per 24-hour period for at least 2 consecutive days. 只要病人自訴服用了 >12 g,就有 30% 病人的 4-hr ACT level 會 >200 mg/dL 及 6% 會出現 hepatotoxicity. [Tintinalli-7, Chp 184]
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